Amantadine Resistant of Indonesian H5N1 Subtype Influenza Viruses During 2003-2008
نویسندگان
چکیده
منابع مشابه
Distribution of amantadine-resistant H5N1 avian influenza variants in Asia.
We examined the distribution of genetic mutations associated with resistance to the M2 ion channel-blocking adamantane derivatives, amantadine and rimantadine, among H5N1 viruses isolated in Vietnam, Thailand, Cambodia, Indonesia, Hong Kong, and China. More than 95% of the viruses isolated in Vietnam and Thailand contained resistance mutations, but resistant mutants were less commonly isolated ...
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Background and Aims: Influenza A viruses are important pathogens for humans especially in pandemic episodes. Two adamantane derivates, amantadine and rimantadine, are used for prophylaxis and treatment of influenza A virus infections. However, single amino acid substitutions in the M2 transmembrane domain which lead to amantadine resistance of these viruses occur at residues 26, 27, 30, 31 or 3...
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Avian influenza is an important disease of poultry with the potential to cause major epidemics resulting in significant economic losses. The presence of avian influenza viruses (AIV) in chickens in Iran has not been previously reported. An avian influenza outbreak in broiler, layer and breeder farms occurred during a very hot summer in July 1998. Three AIV isolates designated as 101, 102 and 10...
متن کاملHigh incidence of amantadine-resistant influenza H1N1 viruses isolated during the 2007-2008 season in Nara Prefecture, Japan.
Amantadine is the first anti-influenza drug licensed in Japan. The drug inhibits virus replication during the early stage of infection by blocking the ion channel formed by the M2 protein. A single substitution at 1 of 4 residues of M2 protein (positions 26, 27, 30 and 31) has been shown to confer resistance to adamantane. In 2005, Bright and colleagues’ genotypic study showed a great increase ...
متن کاملOseltamivir- and Amantadine-Resistant Influenza Viruses A (H1N1)
Surveillance of amantadine and oseltamivir resistance among influenza viruses was begun in Hong Kong in 2006. In 2008, while both A/Brisbane/59/2007-like and A/Hong Kong/2652/2006-like viruses (H1N1) were cocirculating, we detected amantadine and oseltamivir resistance among A/Hong Kong/2652/2006-like viruses (H1N1), caused by genetic reassortment or spontaneous mutation.
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ژورنال
عنوان ژورنال: Microbiology Indonesia
سال: 2010
ISSN: 1978-3477,2087-8575
DOI: 10.5454/mi.4.1.3